{"product_id":"signal-transduction-and-the-coordination-of-b-lymphocyte-development-and-function-i-transduction-of-bcr-signals-from-the-cell-membrane-to-the-topics-in-microbiology-and-immunology","title":"Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the ... Topics in Microbiology and Immunology)","description":"\u003cp\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Justement, Louis B.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBrand:\u003c\/b\u003e Springer\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEdition:\u003c\/b\u003e 2000 ed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBinding:\u003c\/b\u003e hardcover\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat:\u003c\/b\u003e Import\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNumber Of Pages:\u003c\/b\u003e 267\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRelease Date:\u003c\/b\u003e 19-08-1999\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePart Number:\u003c\/b\u003e 18 black \u0026amp; white illustrations, 5 black\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetails:\u003c\/b\u003e Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEAN:\u003c\/b\u003e 9783540660026\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePackage Dimensions:\u003c\/b\u003e 9.3 x 6.1 x 0.6 inches\u003c\/p\u003e\u003cp\u003e\u003cb\u003eLanguages:\u003c\/b\u003e English\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":48960429850928,"sku":"DRGDelhiBookStore_9783540660026","price":5004.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0690\/9968\/4144\/files\/springer-book-default-title-signal-transduction-and-the-coordination-of-b-lymphocyte-development-and-function-i-transduction-of-bcr-signals-from-the-cell-membrane-to-the-topics-in-microbiology-and-immunology-38540484804912.jpg?v=1753007088","url":"https:\/\/www.retailmaharaj.com\/products\/signal-transduction-and-the-coordination-of-b-lymphocyte-development-and-function-i-transduction-of-bcr-signals-from-the-cell-membrane-to-the-topics-in-microbiology-and-immunology","provider":"Retail Maharaj","version":"1.0","type":"link"}